Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length106 amino acids

Chemical FormulaC535H848N138O149S6

DescriptionStandard

        MARGPDSMPQWAILVVLTTMGTAVTAATNPGLLTRISQKGLDYACQKGVAMLQKELEKIKIPDFSGNFKIQHLGKGYYSFYSMTILGFQLPSPQIRLEPQLSQWQV
    

Molecular Weight11789.68 Da

Isoelectric Point (pI)9.42

Net Charge (pH 7.0)3.58

Net Charge (pH 7.4) 3.27

Charge Density (pH 7.0) 0.0338

GRAVY Index-0.05

Hydrophobic Moment 0.64

Boman Index0.12

Instability Index32.59

Aliphatic Index 90.19

Aromaticity 0.0943

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 16960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4590.41

LogP -39.57

H-bond Donors 156.0

H-bond Acceptors 160.0

Rotatable Bonds 388.0

Heavy Atoms 828.0

Ring Count 20.0

Amide Bonds 117.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054175 VERIFIED: NO

Provenance & Taxonomy

OrganismMarmota monax [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence