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MYP_083120
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Basic Information
Grammistin Gs 1 (Grammistin Gs F; Group I grammistin; soapfish, chordates, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Ichthyotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C130H210N36O32
Standard
Sequence
LFGFLIKLIPSLFGALSNIGRNRNQ
Physicochemical Analysis
2789.28 Da
12.00
2.76
2.55
0.1104
0.46
0.58
0.20
30.40
128.80
0.1200
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1115.57
-8.92
38.0
35.0
93.0
198.0
4.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0101480 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic Ichthyotoxic
Horse erythrocytes
1.9 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/10669014/ PMID10669014 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10669014/
RECORD: Rec_0106581 VERIFIED: YES
Provenance & Taxonomy
Grammistes sexlineatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio parahaemolyticus
25 μg/mL
MIC
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02376
RECORD: Rec_0139243 VERIFIED: YES
Provenance & Taxonomy
Grammistes sexlineatus [Animal]
Grammistin; Group 1 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Cytolytic Toxin Hemolytic Ichthyotoxic
PMID10669014;15777955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10669014/
RECORD: Rec_0215753 VERIFIED: YES
Provenance & Taxonomy
Grammistes sexlineatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
dameselae subsp
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02376
RECORD: Rec_0244810 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Toxic Hemolytic Cytotoxic Ichthyona
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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