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MYP_083091
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Basic Information
RMP-16 (Recombinant slow-release TNF α-derived peptide)
Anticancer
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
32 amino acids
C171H275N49O46S
Standard
Sequence
MWQRPSSWIEGRLLTHTISRIAVSYQTKVNLL
Physicochemical Analysis
3785.38 Da
10.90
2.59
2.32
0.0809
-0.13
0.70
0.02
42.48
106.56
0.0938
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1557.02
-13.36
57.0
51.0
123.0
267.0
7.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188780 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
TNF alpha-derived
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Rat plasma: The half-life is 15.83 h
PaperMa Y, Zhao S, Shen S, Fang S, Ye Z, Shi Z, Hong A A novel recombinant slow-release TNF α-derived peptide effectively inhibits tumor growth and angiogensis. Sci Rep. 2015 Sep 4;5:13595. PMID:26337231 https://pubmed.ncbi.nlm.nih.gov/26337231/ PMID26337231 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26337231/
RECORD: Rec_0218985 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Anti-angiogenic
0.0172±0.00195 μM
IC50
BALB/c mice plasma (Dose i/v injected), in vivo; 47196 s
PMID26337231 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26337231/