Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length488 amino acids

Chemical FormulaC2415H3821N621O696S18

DescriptionStandard

        MARDPDNTLRWATLMVLAALGTAVTEATNPGIVVRITQKGLDYACQQGVAVLQKELEKITIPSFSGSFKIKYLGKGDYSFYSLVIREVQLPSSQIRLLPNEGLAFSVTNANVKISGKWKARKNFIKTSGNFDLSVEGISISAGLKLSCDPASGHSTVTCSSCRNHIDSVHLHVSGSQLGWLIQLFHNKIESSLQNAMNNKICEVVTSSVSSKLEPFFQTLPVTASIDNVAGIDYSLLAPPIATTETLDGQLKGEFFSLAHRSPPPFAPPALAFPADHDHMVYLGISDYFFNTAGLVYQQAGVLNLTLKDDMIPKESKIRLTTKFFGTLIPQVAKMFPNMNMEILIRASSPPYLTVSPAGLAFTPALEAQAFAVLPNSSLAPLFLLGMVSCSRSANVSVEVGAMSDRLVGELDLDKLLLELKHSDIGPFSIELLQSIMNYVVPSIVLPKVNEKLQKGFPLPMPSRVQLYNLVLQPYQEFLLFGADVHYR
    

Molecular Weight53268.08 Da

Isoelectric Point (pI)7.14

Net Charge (pH 7.0)0.35

Net Charge (pH 7.4) -0.56

Charge Density (pH 7.0) 0.0007

GRAVY Index0.14

Hydrophobic Moment 0.66

Boman Index0.15

Instability Index43.03

Aliphatic Index 101.50

Aromaticity 0.0840

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0263614 VERIFIED: NO

Provenance & Taxonomy

OrganismMolossus molossus (Pallas` mastiff bat) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria