Peptide Database

Peptide NameSLAY-screened peptide P2891

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC98H146N24O29S

DescriptionStandard

        CAPPDIIHLFNATGSNFPEL
    

Molecular Weight2156.42 Da

Isoelectric Point (pI)4.35

Net Charge (pH 7.0)-2.16

Net Charge (pH 7.4) -2.43

Charge Density (pH 7.0) -0.1079

GRAVY Index0.22

Hydrophobic Moment 0.37

Boman Index0.29

Instability Index37.72

Aliphatic Index 88.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 819.77

LogP -7.17

H-bond Donors 26.0

H-bond Acceptors 29.0

Rotatable Bonds 62.0

Heavy Atoms 152.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0050391 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/