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MYP_082858
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Basic Information
Brevinin-2CG1 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C148H256N42O45S2
Standard
Sequence
GILDKLKEFGISAARGVAQSLLNTASCKLAKTC
Physicochemical Analysis
3408.00 Da
9.31
2.74
2.50
0.0830
0.30
0.51
0.09
18.15
106.67
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1422.43
-16.02
52.0
50.0
119.0
237.0
1.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0170380 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
Human erythrocytes
75 μM
LC50
RECORD: Rec_0235735 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/E1AWD6/entry
RECORD: Rec_0242108 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0400329 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
faecalis X29
PaperPubMed PMID: 22951323 PMID22951323 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22951323/
RECORD: Rec_0400605 VERIFIED: YES
Provenance & Taxonomy
Amolops chunganensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
150 μM
MIC
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