Peptide Database

Peptide NameSLAY-screened peptide P5849

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H163N25O30S2

DescriptionStandard

        SDYSISLCVSIICNKYLAVR
    

Molecular Weight2247.63 Da

Isoelectric Point (pI)7.77

Net Charge (pH 7.0)0.44

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0219

GRAVY Index0.76

Hydrophobic Moment 0.30

Boman Index0.19

Instability Index17.57

Aliphatic Index 131.50

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 905.91

LogP -8.36

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 73.0

Heavy Atoms 156.0

Ring Count 2.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0018494 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/