Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length455 amino acids

Chemical FormulaC2223H3519N571O668S12

DescriptionStandard

        MKLWVPLVLLVCGATKCEEPGIKGRLTLKGLHYGWQVVLEEVQRRLSSLQIPDVSGSVSVPVLGAIYYSVSSLQIQELDLSHSDASFSSDTGLKVSVSDGRTRVTGYIEIRTVLFGTSSSLEVSVDGLSLSAVLGLTRDDAGRGALWNAGCSSSVGQVDLNFHGGSGWILSMFKGSMLGPIHDAFSQQLCPQFDRSVVQMETLLSSLPVTEPVDSVAALELSLVSPPLITEQNVDLLVRGQFVGLSQRWDVPYSPVEMDLPDAESRMLVLAVSQFSANSASYVHYKSGALRANITDDMIPKESPLRLNTKSFAAFAPELPNRFPGSPPLLLQLSAPSPPEVTCQTDLLTLGASLDIQLSALYPESPPAPAFQLQADFETEINILLSEEALGATLKLQKVFPIPTPLVRLQSPTVRVFQGFLLVVSDLEIDPWTQYQKVSDVAWEIPKTHKPSPFL
    

Molecular Weight49316.93 Da

Isoelectric Point (pI)4.82

Net Charge (pH 7.0)-15.96

Net Charge (pH 7.4) -16.64

Charge Density (pH 7.0) -0.0351

GRAVY Index0.12

Hydrophobic Moment 0.63

Boman Index0.14

Instability Index51.60

Aliphatic Index 103.85

Aromaticity 0.0725

Extinction Coeff. Reduced 51910.00

Extinction Coeff. Oxidized 52160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296119 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria