Peptide Database

Peptide NameHuman C1-esterase inhibitor

Function Ontology

Hemostasis ▸ Fibrinolytic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length500 amino acids

Chemical FormulaC2458H3933N641O757S18

DescriptionStandard

        MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA
    

Molecular Weight55153.53 Da

Isoelectric Point (pI)6.09

Net Charge (pH 7.0)-4.61

Net Charge (pH 7.4) -5.50

Charge Density (pH 7.0) -0.0092

GRAVY Index-0.12

Hydrophobic Moment 0.73

Boman Index0.06

Instability Index33.71

Aliphatic Index 89.70

Aromaticity 0.0680

Extinction Coeff. Reduced 26930.00

Extinction Coeff. Oxidized 27180.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0047489 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyCoagulation factor

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Coagulation factor replacement Thrombolytic Fibrinolytic

Half-LifeThe half life of a 50 IU/kg dose is 2.4 ± 0.6 h, while the half life of a 100 IU/kg dose is 2.7 ± 0.3 h.[L16591] Subcutaneous administration produces a half life of 199.6 hours.[A19661]

RECORD: Rec_0230546 VERIFIED: NO