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MYP_082520
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Basic Information
Ascaphin-3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C114H187N33O29
Standard
Sequence
GFRDVLKGAAKAFVKTVAGHIANI
Physicochemical Analysis
2483.91 Da
10.29
2.85
2.59
0.1186
0.49
0.74
0.20
34.39
105.83
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1001.88
-8.52
35.0
33.0
83.0
176.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0057652 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli
6 μM
MIC
PaperThe ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei.
RECORD: Rec_0067309 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
200
HC50
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0142223 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0146610 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic
Gram-negative and Gram-positive bacteria
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0166396 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
200.0 μM
HC50
PaperJ.M. Conlon et al. / Biochemical and Biophysical Research Communications 320 (2004) 170-175. The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei Evidence URLhttps://www.uniprot.org/uniprotkb/P0CJ27/entry
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