Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2568H3998N636O744S19

DescriptionStandard

        MRTKAVQVLWGCFFLWNLCSSSTQTIYPGIKARVTQRALDYGIQAGMEMIEQMIKEKNIPDLKGSESLEFLKVDYVNYNFSNIKINVFSFPNTSLAFVPGVGIKALTNHGTANISTNWDVKSPLFQDTGEADLFLSGVYFTGIIVLSQNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYIELNLKGVFYPLDNLTDPPFLPVPFALPERSDSMLYVGISEFFFKSASFAYFIAGAFNVTLSMKEISNHLVQNSQGLGNMLSRIAEIYILSQPFMVRVMATEPPVISLLPGNFTLDIPASIVILTQPENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESSRSNIEVLRFENILSSILHFGILPLANAKLQQGIPLPNPHKISFVNSDVEVFEGFLLISTDLKYETSLKQQPSFHGWEGLSLMSGQWRGKPAA
    

Molecular Weight56294.26 Da

Isoelectric Point (pI)5.10

Net Charge (pH 7.0)-13.78

Net Charge (pH 7.4) -14.59

Charge Density (pH 7.0) -0.0272

GRAVY Index0.18

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index37.20

Aliphatic Index 103.43

Aromaticity 0.1026

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065173 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus dingo [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

RECORD: Rec_0192715 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyBPI/LBP

Tax ID9615