Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC210H333N49O74S4

DescriptionStandard

        MKELFVDLSAVEDITEAELQAAVAPDDGWITTLTDDCPNSIIVCC
    

Molecular Weight4856.43 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-9.51

Net Charge (pH 7.4) -9.78

Charge Density (pH 7.0) -0.2114

GRAVY Index0.36

Hydrophobic Moment 0.39

Boman Index0.21

Instability Index29.98

Aliphatic Index 106.22

Aromaticity 0.0444

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1948.51

LogP -17.94

H-bond Donors 67.0

H-bond Acceptors 69.0

Rotatable Bonds 156.0

Heavy Atoms 337.0

Ring Count 5.0

Amide Bonds 46.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390466 VERIFIED: NO

Provenance & Taxonomy

OrganismPaenibacillus sp. CFBP13512 [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence