Peptide Database

Peptide NameP-54

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC134H226N34O47

DescriptionStandard

        YTSLIEELIKKSEEQQKKNEEELKK
    

Molecular Weight3065.43 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-1.23

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0491

GRAVY Index-1.66

Hydrophobic Moment 0.57

Boman Index-0.43

Instability Index92.26

Aliphatic Index 78.00

Aromaticity 0.0400

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1389.13

LogP -12.19

H-bond Donors 46.0

H-bond Acceptors 46.0

Rotatable Bonds 117.0

Heavy Atoms 215.0

Ring Count 1.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0237804 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity0.75 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min

PaperStructural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | Chong H, Zhu Y, Yu D, He Y. | J Virol. 2018 Sep 26;92(20):e01088-18. | DOI:10.1128/JVI.01088-18 | PMID:30089693 PMID30089693 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30089693/

RECORD: Rec_0387762 VERIFIED: YES