Peptide Database

Peptide NameSHP4

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC45H72N10O14S

DescriptionStandard

        VPSLTQSMF
    

Molecular Weight1009.18 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-0.27

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0296

GRAVY Index0.59

Hydrophobic Moment 0.36

Boman Index0.31

Instability Index92.13

Aliphatic Index 75.56

Aromaticity 0.1111

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 391.11

LogP -3.89

H-bond Donors 13.0

H-bond Acceptors 15.0

Rotatable Bonds 30.0

Heavy Atoms 70.0

Ring Count 2.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0087630 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFITC, 5(6)-carboxy fluorescence

C-TermNone

Other ModsStapled: Ⓧ(3) and Ⓧ (7) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer Antimicrobial Antibacterial

PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13886. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/