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MYP_082113
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Basic Information
Phylloseptin-3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
19 amino acids
C89H141N25O24
Standard
Sequence
FLSLIPHAINAVSALANHG
Physicochemical Analysis
1945.22 Da
6.92
-0.07
-0.37
-0.0035
0.93
0.46
0.45
2.50
138.95
0.0526
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
762.33
-6.86
25.0
26.0
59.0
138.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063011 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Resende et al. / Peptides 29 (2008) 1633-1644. Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: The role of charges and hydrogen bonding interactions in stabilizing helix conformations Evidence URLhttps://www.uniprot.org/uniprotkb/P84568/entry
RECORD: Rec_0106481 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPhylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
RECORD: Rec_0116922 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0120820 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
frog skin active peptide (FSAP) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial frog skin active peptide (FSAP) family Host defense
PaperPDB 2JQ1 structural record; NMR; chain A; residues 1-19
RECORD: Rec_0132977 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
65.6 μM
MIC
PMID15752569;18656510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
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