Peptide Database

Peptide NameSynenkephalin

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC223H352N60O76S3

DescriptionStandard

        ACTLECEGKLPSAKAWGTCKELLQLTKLDGVQDGEKYQDNNDSHYIA
    

Molecular Weight5185.73 Da

Isoelectric Point (pI)4.75

Net Charge (pH 7.0)-3.14

Net Charge (pH 7.4) -3.44

Charge Density (pH 7.0) -0.0668

GRAVY Index-0.69

Hydrophobic Moment 0.44

Boman Index-0.08

Instability Index61.16

Aliphatic Index 72.77

Aromaticity 0.0638

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2223.16

LogP -24.16

H-bond Donors 77.0

H-bond Acceptors 77.0

Rotatable Bonds 176.0

Heavy Atoms 362.0

Ring Count 6.0

Amide Bonds 51.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0148347 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilySynenkephalin

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0191565 VERIFIED: NO