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MYP_082061
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Basic Information
Brevinin-1CHc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
19 amino acids
C100H160N22O23S2
Standard
Sequence
FFPTIAGLTKLFCAITKKC
Physicochemical Analysis
2102.60 Da
9.39
2.74
2.50
0.1441
0.94
0.56
0.33
15.14
92.63
0.1579
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
717.08
-3.40
27.0
28.0
67.0
147.0
4.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183942 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
13-19
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
20.0 μM
MIC
PaperJ.M. Conlon et al. / Peptides 32 (2011) 664-669. Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona
RECORD: Rec_0241944 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
80 μM
MIC
RECORD: Rec_0267352 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0287970 VERIFIED: YES
Provenance & Taxonomy
Rana chiricahuensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
13-19
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
RECORD: Rec_0362122 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
20 μM
MIC
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