Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length168 amino acids

Chemical FormulaC808H1293N221O223S7

DescriptionStandard

        MLLLAVTEFVANSAAFAYFTAGALRRNITSDMLPRRFPLQLKTKSMGLFSPQVGTGQGAVPSAGQDLSARRQPLLSCHPDALYGSLFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLGGTVSLKGALLVLQVKRLENMLKFGLWLFGVPQANSECCPHPVP
    

Molecular Weight17895.71 Da

Isoelectric Point (pI)9.85

Net Charge (pH 7.0)6.65

Net Charge (pH 7.4) 6.27

Charge Density (pH 7.0) 0.0396

GRAVY Index0.25

Hydrophobic Moment 0.59

Boman Index0.16

Instability Index53.87

Aliphatic Index 98.15

Aromaticity 0.0774

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7005.16

LogP -71.13

H-bond Donors 241.0

H-bond Acceptors 239.0

Rotatable Bonds 574.0

Heavy Atoms 1259.0

Ring Count 29.0

Amide Bonds 182.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152863 VERIFIED: NO

Provenance & Taxonomy

OrganismEgretta garzetta [Animal]

FamilyBPI/LBP

Tax ID188379

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria