Peptide Database

Peptide NameSLAY-screened peptide P5413

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H168N28O28S

DescriptionStandard

        VLSFLSKLLCPSVHRTTNNL
    

Molecular Weight2242.64 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)1.81

Net Charge (pH 7.4) 1.53

Charge Density (pH 7.0) 0.0905

GRAVY Index0.43

Hydrophobic Moment 0.51

Boman Index0.12

Instability Index17.00

Aliphatic Index 126.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 911.36

LogP -9.32

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 72.0

Heavy Atoms 157.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0214722 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/