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MYP_082006
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Basic Information
SR9
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
35 amino acids
C168H287N47O58
Standard
Sequence
ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL
Physicochemical Analysis
3893.36 Da
4.36
-3.23
-3.44
-0.0922
-0.08
0.70
0.02
43.51
142.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1752.78
-18.20
57.0
55.0
139.0
273.0
0.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250293 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV; Vero E6 cells
0.005 μM
EC50
PMID17942557;18442051;32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0250946 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG8-K(Chol)
PEG8-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/
RECORD: Rec_0259634 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Fusion inhibition
SARS-CoV-2; cell-cell fusion system
0.72 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperStructural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. | Sun H, Li Y, Liu P, Qiao C, Wang X, Wu L, Liu K, Hu Y, Su C, Tan S, Zou S, Wu G, Yan J, Gao GF, Qi J, Wang Q. | Emerg Microbes Infect. 2020 Dec;9(1):1238-1241. | DOI:10.1080/22221751.2020.1770631 | PMID:32482145 PMID32482145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32482145/
RECORD: Rec_0263204 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV pseudovirus; 293T/ACE2 cells
50 μM
IC50
PMID17942557;18442051;32376627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17942557/
RECORD: Rec_0271425 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG8-K(Chol)
PEG8-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 D614G; cell-cell fusion system
0.0006±0.0001 μM
IC50
PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/
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