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MYP_081971
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C98H153N25O23
Standard
Sequence
FLSLIPHAINAVSAIAKHF
Physicochemical Analysis
2049.42 Da
8.76
0.93
0.63
0.0491
1.11
0.53
0.47
2.50
138.95
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
745.26
-4.00
25.0
26.0
63.0
146.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283332 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.6 μM
MIC
PaperA.H. Thompson et al. / Peptides 28 (2007) 1331-1343. A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea Evidence URLhttps://www.uniprot.org/uniprotkb/P84572/entry
RECORD: Rec_0313675 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 12600
3.6 μM
MIC
PMID17553595;16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17553595/
RECORD: Rec_0318470 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
6 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/16963159/ PMID16963159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16963159/
RECORD: Rec_0323378 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa azurea [Animal]
Phylloseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 11775
7.2 μM
MIC
PMID17553595 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17553595/
RECORD: Rec_0340793 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa palliata [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Non-hemolytic
Evidence URLhttps://www.uniprot.org/uniprotkb/P86710/entry
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