‹ ›
MYP_081877
← PREVIOUS NEXT → BACK
Basic Information
Neutrophil defensin 3 (Defensin, alpha 3; HNP-3, HP-3, HP3; Human, mammals, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
30 amino acids
C151H228N44O40S6
Standard
Sequence
DCYCRIPACIAGERRYGTCIYQGRLWAFCC
Physicochemical Analysis
3492.09 Da
8.33
1.70
1.40
0.0567
0.12
0.49
0.02
41.06
62.00
0.1667
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1360.43
-11.47
56.0
48.0
107.0
241.0
7.0
30.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0243318 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Homo sapiens
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Fibrosarcoma (Fibrous connective tissue)
PMID4056036;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4056036/
RECORD: Rec_0260826 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization of a C-terminal Cys residue (forming a disulfide bond)
2-30, 4-19, 9-29
Disulfide bonds between Cys2 and Cys30,Cys4 and Cys19,Cys9 and Cys29.; Cyclization of a C-terminal Cys residue (forming a disulfide bond)
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | HEK293T-hACE2 cells
1 μg/mL
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. | Xu C, Wang A, Marin M, Honnen W, Ramasamy S, Porter E, Subbian S, Pinter A, Melikyan GB, Lu W, Chang TL. | Viruses. 2021 Jun 26;13(7):1246. | DOI:10.3390/v13071246 | PMID:34206990 PMID34206990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0276198 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0286572 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
2-30; 4-19; 9-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-SARS-CoV-2
Enterobacter aerogenes ATCC 13048 (vLD50=41±9.2 μg/ml)
PaperHuman Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry. Viruses. 2021 Jun 26;13(7):1246. doi: 10.3390/v13071246. PMID: 34206990. | PubMed PMID: 4056036 | Antibacterial activity and specificity of the six human alpha-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-275. doi: 10.1128/AAC.49.1.269-275.2005. PMID: 15616305. PMID34206990;4056036;15616305 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34206990/
RECORD: Rec_0324762 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
alpha-defensin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-30; 4-19; 9-29
Bio-Activity Profile
Antimicrobial alpha-defensin family Antibacterial Antifungal Antiviral Host defense Defensin-like
PaperPDB 1DFN structural record; X-ray; 1.90 A; chain A/B; residues 1-30
FIRST PREV 1 ... 3 4 5 6 7 NEXT LAST
Showing 5 records on this page · Page 5 of 7