Peptide Database

Peptide NameSLAY-screened peptide P4918

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H160N22O29S3

DescriptionStandard

        IIGTVCNCLSYYWAYCLYTL
    

Molecular Weight2362.78 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-0.27

Net Charge (pH 7.4) -0.53

Charge Density (pH 7.0) -0.0137

GRAVY Index1.08

Hydrophobic Moment 0.38

Boman Index0.49

Instability Index12.30

Aliphatic Index 117.00

Aromaticity 0.2500

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11585.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 816.71

LogP -2.92

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 68.0

Heavy Atoms 165.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0253803 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/