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MYP_081830
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C74H118N16O17
Standard
Sequence
ILGKIWEGIKSIF
Physicochemical Analysis
1503.83 Da
8.59
0.76
0.55
0.0585
0.83
0.61
0.43
-2.08
150.00
0.1538
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
537.88
-0.21
19.0
18.0
51.0
107.0
3.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0297528 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HSV-1
0.43 ± 0.09 μM
EC50
PMID24315793 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24315793/
RECORD: Rec_0300829 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
754296
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
Inhibition of viral attachment in Vero cells
2.87±0.16 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperInhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. | Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z. | Antiviral Res. 2014 Feb;102:1-10. | DOI:10.1016/j.antiviral.2013.11.013 | PMID:24315793 PMID24315793 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24315793/
RECORD: Rec_0323076 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human RBC ( HC50 = 34.91 +/- 0.47 microM ) [HC50
34.91 ± 0.47 μM
Hemolysis
PMID24315793 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24315793/
RECORD: Rec_0330114 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
754296
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
Inhibition of viral entry in Vero cells
4.29±0.35 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperInhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. | Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z. | Antiviral Res. 2014 Feb;102:1-10. | DOI:10.1016/j.antiviral.2013.11.013 | PMID:24315793 PMID24315793 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24315793/
RECORD: Rec_0336648 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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