Peptide Database

Peptide NameCanakinumab

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ IL-1beta inhibitor

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length173 amino acids

Chemical FormulaC831H1263N223O252S5

DescriptionStandard

        QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPGKGLEWVAIIWYDGDNQYYADSVKGRFTISRDNSKNTLYLQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPA
    

Molecular Weight18569.59 Da

Isoelectric Point (pI)8.46

Net Charge (pH 7.0)1.82

Net Charge (pH 7.4) 1.49

Charge Density (pH 7.0) 0.0105

GRAVY Index-0.15

Hydrophobic Moment 0.54

Boman Index0.10

Instability Index37.30

Aliphatic Index 70.98

Aromaticity 0.1214

Extinction Coeff. Reduced 40910.00

Extinction Coeff. Oxidized 41035.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7585.56

LogP -86.35

H-bond Donors 270.0

H-bond Acceptors 260.0

Rotatable Bonds 586.0

Heavy Atoms 1311.0

Ring Count 36.0

Amide Bonds 185.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340408 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory IL-1beta inhibitor

Half-Life26 d