Peptide Database

Peptide NameSLAY-screened peptide P3475

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC46H64N12O11S3

DescriptionStandard

        CFPDCWMR
    

Molecular Weight1057.27 Da

Isoelectric Point (pI)5.82

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.49

Charge Density (pH 7.0) -0.0323

GRAVY Index-0.10

Hydrophobic Moment 0.58

Boman Index-0.01

Instability Index73.17

Aliphatic Index 0.00

Aromaticity 0.2500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 373.22

LogP -1.38

H-bond Donors 15.0

H-bond Acceptors 14.0

Rotatable Bonds 29.0

Heavy Atoms 72.0

Ring Count 4.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0041922 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/