Peptide Database

Peptide NamePonericin-W3 (ants, insects, animals)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Insecticidal/Pest control ▸ Insecticidal activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC133H235N37O30S

DescriptionStandard

        GIWGTLAKIGIKAVPRVISMLKKKKQ
    

Molecular Weight2864.58 Da

Isoelectric Point (pI)11.43

Net Charge (pH 7.0)6.75

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.2598

GRAVY Index0.11

Hydrophobic Moment 0.71

Boman Index0.06

Instability Index-0.37

Aliphatic Index 120.00

Aromaticity 0.0385

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1099.39

LogP -6.30

H-bond Donors 39.0

H-bond Acceptors 38.0

Rotatable Bonds 102.0

Heavy Atoms 201.0

Ring Count 3.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0096591 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

FamilyPonericin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa CIP A22

RECORD: Rec_0100275 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal Antifungal Hemolytic

Targethorse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 μl of the peptide solution and placed overnight at 4℃ to allow the diffusion of the hemolytic agent)

RECORD: Rec_0125495 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal Antifungal

TargetKlebsiella pneumoniae CIP 8291(Inhibition zone = 7.5mm)

RECORD: Rec_0138385 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal Antifungal

Targetmegaterium ATCC 9885b(Inhibition zone = 13.5mm)

RECORD: Rec_0146678 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

FamilyPonericin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetP. putidaLMA

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