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MYP_081686
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Basic Information
Circulin-C (CIRC; Plant defensin)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
30 amino acids
C131H214N36O40S6
Standard
Sequence
GIPCGESCVFIPCITSVAGCSCKSKVCYRN
Physicochemical Analysis
3125.71 Da
8.33
1.70
1.40
0.0567
0.56
0.32
0.17
18.66
71.33
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1205.35
-15.13
48.0
48.0
98.0
213.0
4.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283696 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 (HIV-1 205)
0.155 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia. | Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR. | J Nat Prod. 2000 Feb;63(2):176-8. | DOI:10.1021/np990432r | PMID:10691702 PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0300629 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 (HIV-1 IIIB)
0.073 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia. | Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR. | J Nat Prod. 2000 Feb;63(2):176-8. | DOI:10.1021/np990432r | PMID:10691702 PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0311404 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
50-275
EC50
PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0312831 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 0.0%, E 6.7%, T 53.3%, C 40.0% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0313318 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
NOTE: EC50 = concentration that is 50% effective
PaperPubMed PMID: 10691702 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10691702;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
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