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MYP_081686
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Basic Information
Circulin-C (CIRC; Plant defensin)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
30 amino acids
C131H214N36O40S6
Standard
Sequence
GIPCGESCVFIPCITSVAGCSCKSKVCYRN
Physicochemical Analysis
3125.71 Da
8.33
1.70
1.40
0.0567
0.56
0.32
0.17
18.66
71.33
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1205.35
-15.13
48.0
48.0
98.0
213.0
4.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018768 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 (HIV-1 IIIB) | MT-2 cells
0.2 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia. | Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR. | J Nat Prod. 2000 Feb;63(2):176-8. | DOI:10.1021/np990432r | PMID:10691702 PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0066970 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
e.g., HIV-1 strain IIIB/CEM-SS cell
0.073 μM
EC50
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia.
RECORD: Rec_0088041 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 (HIV-1 H1122) | MT-2 cells
0.048 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia. | Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR. | J Nat Prod. 2000 Feb;63(2):176-8. | DOI:10.1021/np990432r | PMID:10691702 PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0093581 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 (HIV-1 G)
0.111 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia. | Gustafson KR, Walton LK, Sowder RC Jr, Johnson DG, Pannell LK, Cardellina JH Jr, Boyd MR. | J Nat Prod. 2000 Feb;63(2):176-8. | DOI:10.1021/np990432r | PMID:10691702 PMID10691702 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0096515 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
A17 strain/MT-2
0.247 μM
EC50
PaperNew circulin macrocyclic polypeptides from Chassalia parvifolia.
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