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MYP_081613
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Basic Information
Figainin 2, Figainin-02
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C142H236N36O33S
Standard
Sequence
FLGAILKIGHALAKTVLPMVTNAFKPKQ
Physicochemical Analysis
3007.68 Da
10.48
3.84
3.58
0.1373
0.57
0.57
0.28
3.59
118.57
0.0714
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1090.84
-5.95
36.0
39.0
99.0
212.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130937 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Boana raniceps [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Antiparasitic
Trypanosoma epimastigotes form T. cruzi
6.3 μM
MIC
PaperBiological Properties of a Novel Multifunctional Host Defense Peptide From the Skin Secretion of the Chaco Tree Frog, Boana raniceps
RECORD: Rec_0145570 VERIFIED: YES
Provenance & Taxonomy
Boana raniceps [Animal]
192750
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Infection inhibition
Chikungunya virus (CHIKV) | Huh7 cells
17 μM
EC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBiological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps. | Santana CJC, Magalhães ACM, Prías-Márquez CA, Falico DA, Dos Santos Júnior ACM, Lima BD, Ricart CAO, de Pilger DRB, Bonotto RM, Moraes CB, Freitas-Júnior LH, Álvares ADCM, Freitas SM, Luz IS, Pires OR Jr, Fontes W, Castro MS. | Biomolecules. 2020 May 20;10(5):790. | DOI:10.3390/biom10050790 | PMID:32443921 PMID32443921 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32443921/
RECORD: Rec_0152363 VERIFIED: YES
Provenance & Taxonomy
Boana raniceps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal
Escherichia coli ATCC 25922
8 μM
MIC
PMID32443921 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32443921/
RECORD: Rec_0159552 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0162174 VERIFIED: YES
Provenance & Taxonomy
Boana raniceps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus ATCC 25923
8 μM
MIC
PMID32443921 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32443921/
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