Peptide Database

Peptide NameSLAY-screened peptide P5643

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC116H161N31O31S2

DescriptionStandard

        PRYYDTVNMHCLPFYWSNSR
    

Molecular Weight2549.84 Da

Isoelectric Point (pI)8.57

Net Charge (pH 7.0)1.03

Net Charge (pH 7.4) 0.91

Charge Density (pH 7.0) 0.0517

GRAVY Index-0.89

Hydrophobic Moment 0.35

Boman Index-0.11

Instability Index90.73

Aliphatic Index 34.00

Aromaticity 0.2500

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1006.57

LogP -8.18

H-bond Donors 38.0

H-bond Acceptors 35.0

Rotatable Bonds 74.0

Heavy Atoms 180.0

Ring Count 9.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412711 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/