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MYP_081485
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Basic Information
Vitri peptide A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C134H217N37O40S6
Standard
Sequence
GIPCGESCVWIPCITSAIGCSCKSKVCYRN
Physicochemical Analysis
3178.77 Da
8.33
1.70
1.40
0.0567
0.45
0.35
0.17
18.66
74.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1221.14
-14.26
49.0
48.0
99.0
217.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0398022 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola biflora [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human prostate cancer DU145
3.07 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 14987040 PMID14987040;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14987040/
RECORD: Rec_0398193 VERIFIED: NO
Provenance & Taxonomy
Viola biflora [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0404139 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola biflora [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human hepatocarcinoma BEL-7402
4.94 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 14987040 PMID14987040;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14987040/
RECORD: Rec_0418457 VERIFIED: NO
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperVitri peptide A Evidence URLhttps://www.uniprot.org/uniprotkb/P83840/entry
RECORD: Rec_0418680 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola biflora [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human glioblastoma U251-MG
6.03 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 14987040 PMID14987040;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14987040/
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