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MYP_081485
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Basic Information
Vitri peptide A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C134H217N37O40S6
Standard
Sequence
GIPCGESCVWIPCITSAIGCSCKSKVCYRN
Physicochemical Analysis
3178.77 Da
8.33
1.70
1.40
0.0567
0.45
0.35
0.17
18.66
74.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1221.14
-14.26
49.0
48.0
99.0
217.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0322743 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 16.7%, E 0.0%, T 50.0%, C 33.3% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0337713 VERIFIED: NO
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0348688 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Cytotoxic Anticancer
U-937 GTB (lymphoma)(IC50 = 0.6 μM) and RPMI-8226/s (myeloma)
1 μM
IC50
PaperPubMed PMID: 18191970 PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0351528 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Hemolytic
human type O red blood cells
PaperPubMed PMID: 18191970 PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0395266 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola biflora [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human histiocytic lymphoma U-937/GTB
0.6 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 14987040 PMID14987040;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14987040/
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