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MYP_081457
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Basic Information
HIV-1 integrase(95-109)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
15 amino acids
C86H129N21O21
Standard
Sequence
QETAYFLLKLAGRWP
Physicochemical Analysis
1793.07 Da
8.59
0.76
0.55
0.0507
-0.17
0.50
0.11
49.04
91.33
0.2000
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
686.49
-2.68
24.0
22.0
55.0
128.0
5.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0159482 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Integrase inhibition
HIV-1
3.5 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperInterfacial peptide inhibitors of HIV-1 integrase activity and dimerization. | Zhao L, O'Reilly MK, Shultz MD, Chmielewski J. | Bioorg Med Chem Lett. 2003 Mar 24;13(6):1175-7. | DOI:10.1016/s0960-894x(03)00040-4 | PMID:12643937 PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0238562 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
3.5 μM
IC50
PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0255725 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
3.5 μM
IC50
PaperInterfacial peptide inhibitors of HIV-1 integrase activity and dimerization. PMID12643937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12643937/
RECORD: Rec_0283503 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/