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MYP_081437
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Basic Information
Cycloviolacin-O8 (Cyclotide c1; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C136H221N35O41S6
Standard
Sequence
GTLPCESCVWIPCISSVVGCSCKSKVCYKN
Physicochemical Analysis
3194.81 Da
8.33
1.70
1.40
0.0566
0.50
0.34
0.17
33.67
77.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1205.49
-13.78
48.0
49.0
100.0
218.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0040229 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-21; 9-23; 14-28
Bio-Activity Profile
Insecticidal
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 PMID16872274;10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0109621 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0115567 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0123264 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-21; 9-23; 14-28
Bio-Activity Profile
Insecticidal Cytotoxic Anticancer
Cytotoxicity against three cancer cell lines: MDA-MB-231 breast (IC50=1.15 μM), PC-3 prostate (IC50=1.05 μM), and OVCAR-3 ovarian
0.8 μM
IC50
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 PMID16872274;10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0170679 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-21; 9-23; 14-28
Bio-Activity Profile
Insecticidal Cytotoxic Anticancer
non-cancerous human dermal fibroblast cells was determined to be ∼3× less (3.13 μM) than cancer cell lines
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 PMID16872274;10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
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