Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length466 amino acids

Chemical FormulaC2356H3671N583O687S20

DescriptionStandard

        MLPRLEMRTKAVQVLWGCFFLWNLCSSSTQTIYPGIKARVTQRALDYGIQAGMEMIEQMIKEKNIPDLKGSESLEFLKVDYVNYNFSNIKINVFSFPNTSLAFVPGVGIKALTNHGTANISTNWDVKSPLFQDTGEADLFLSGVYFTGIIVLSQNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYIELNLKGVFYPLDNLTDPPFLPVPFALPERSDSMLYVGISEFFFKSASFAYFIAGAFNVTLSMKEISNHLVQNSQGLGNMLSRIAEIYILSQPFMVRVMATEPPVISLLPGNFTLDIPASIVILTQPENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESSRSNIEGFLLISTDLKYETSLKQQPSFHGWEGLSLMSGQWRGKPAA
    

Molecular Weight51796.14 Da

Isoelectric Point (pI)5.01

Net Charge (pH 7.0)-12.96

Net Charge (pH 7.4) -13.66

Charge Density (pH 7.0) -0.0278

GRAVY Index0.16

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index35.47

Aliphatic Index 101.24

Aromaticity 0.1030

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0190876 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyBPI/LBP

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence