Peptide Database

Peptide NameSLAY-screened peptide P4714

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC78H127N23O35

DescriptionStandard

        PTNASPISGTSLSSTDSSHT
    

Molecular Weight1946.98 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-0.95

Net Charge (pH 7.4) -1.06

Charge Density (pH 7.0) -0.0477

GRAVY Index-0.60

Hydrophobic Moment 0.12

Boman Index0.01

Instability Index44.83

Aliphatic Index 44.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 925.04

LogP -18.93

H-bond Donors 34.0

H-bond Acceptors 35.0

Rotatable Bonds 59.0

Heavy Atoms 136.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0411175 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/