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MYP_081311
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Basic Information
LTX-315
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
9 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KKWWKKWXK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Dip = diphenylalanine
Bio-Activity Profile
Anticancer Cytotoxic
HT-29
38±3 μM
IC50
PMID21453492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21453492/
RECORD: Rec_0116419 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
None
Amidation
Dip = diphenylalanine
Bio-Activity Profile
Antimicrobial Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0152365 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Dip = diphenylalanine
Bio-Activity Profile
Antimicrobial
Kelly
14±1 μM
IC50
PMID21453492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21453492/
RECORD: Rec_0185229 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Dip = diphenylalanine
Bio-Activity Profile
Antimicrobial
A375
12.7 μM
IC50
PMID24676901 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24676901/
RECORD: Rec_0186791 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived oncolytic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Anticancer
PaperBiophysical Characterization of LTX-315 Anticancer Peptide Interactions with Model Membrane Platforms: Effect of Membrane Surface Charge PMID36142470 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36142470/
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