Peptide Database

Peptide NameSLAY-screened peptide P1893

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H162N36O27

DescriptionStandard

        TRASHARHWHPHLLYYQGTL
    

Molecular Weight2444.71 Da

Isoelectric Point (pI)9.98

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.35

Charge Density (pH 7.0) 0.0872

GRAVY Index-0.90

Hydrophobic Moment 0.36

Boman Index-0.07

Instability Index30.02

Aliphatic Index 68.50

Aromaticity 0.1500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1005.98

LogP -8.05

H-bond Donors 37.0

H-bond Acceptors 33.0

Rotatable Bonds 72.0

Heavy Atoms 175.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0265440 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/