Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length178 amino acids

Chemical FormulaC892H1409N243O239S5

DescriptionStandard

        SLPEALAAREPMLLLAVTEFVPNSAAFAYFTAGALRRNISSDVLPRRFPLQLRTKSMGAFSPQLQEHYPDLPMELHLSARRQPLFSCRPDALHGTLFGSAEAFVVLPNATRVPAFLLNIDANVTGKLTITGHRLRGTVKLTGGSPVPQVKKLETLLKIGLWLFGVPWANSEYCPHPVP
    

Molecular Weight19521.54 Da

Isoelectric Point (pI)9.75

Net Charge (pH 7.0)5.89

Net Charge (pH 7.4) 5.38

Charge Density (pH 7.0) 0.0331

GRAVY Index0.07

Hydrophobic Moment 0.57

Boman Index0.11

Instability Index59.06

Aliphatic Index 97.58

Aromaticity 0.0843

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7557.04

LogP -79.61

H-bond Donors 260.0

H-bond Acceptors 255.0

Rotatable Bonds 615.0

Heavy Atoms 1379.0

Ring Count 40.0

Amide Bonds 188.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0078839 VERIFIED: NO

Provenance & Taxonomy

OrganismPodargus strigoides (Tawny frogmouth) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria