Peptide Database

Peptide NameSebelipase alfa

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length378 amino acids

Chemical FormulaC1968H2945N507O551S15

DescriptionStandard

        SGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
    

Molecular Weight43003.48 Da

Isoelectric Point (pI)6.26

Net Charge (pH 7.0)-4.35

Net Charge (pH 7.4) -5.44

Charge Density (pH 7.0) -0.0115

GRAVY Index-0.17

Hydrophobic Moment 0.81

Boman Index0.11

Instability Index37.80

Aliphatic Index 83.04

Aromaticity 0.1349

Extinction Coeff. Reduced 93850.00

Extinction Coeff. Oxidized 94225.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0083275 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyEnzyme

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsLipidation

Bio-Activity Profile

Function

Enzyme replacement

TargetCHO

Half-Life5.4-6.6 mins