Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length430 amino acids

Chemical FormulaC2124H3453N551O590S16

DescriptionStandard

        MSLWRVLALLMLLPATQTTNAGVKVRITQKGLDYGRQIAIATLLEKLKTIKVPDLSGAEKVSPIGKVQYSLTGIQITALGLPKSAVGLVPGTGISLSIGQAYIRMHGNWKVQYLHIVKDSGSFDLFVNGLAITSGIGLKSDETGRPEVNIASCADSISSASVKFRGGASWLYSLFSSYIDKAIRDTLQKQVNAVLKGIIILKVRWKRKEPPFSAKTFSLPPLASNMLYIGVSEFTANSAGFTYNNAGALSLFITDDMIPPSSPIRLNTRTFGAFIPQIAKRYPRMMMKLLVKMVKAPSITFQQNITTIQASGTITAYAIQPNTTLSPLFILNVGVSFSSLVYVTGVKLSGTVSLNKMDMTLGQSYVGPFQVKSLDKIVLMVLKMVVIPKVNARLQQGFPLPSIGKMNLVNTRVQVLKDFMLIGTDVQFTG
    

Molecular Weight46661.51 Da

Isoelectric Point (pI)10.10

Net Charge (pH 7.0)25.65

Net Charge (pH 7.4) 25.24

Charge Density (pH 7.0) 0.0597

GRAVY Index0.27

Hydrophobic Moment 0.79

Boman Index0.17

Instability Index31.69

Aliphatic Index 107.21

Aromaticity 0.0791

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 39880.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335632 VERIFIED: NO

Provenance & Taxonomy

OrganismDenticeps clupeoides [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence