Peptide Database

Peptide NameSLAY-screened peptide P4440

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC59H97N11O16

DescriptionStandard

        VYIILTDPGLL
    

Molecular Weight1216.47 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.27

Net Charge (pH 7.4) -1.48

Charge Density (pH 7.0) -0.1151

GRAVY Index1.55

Hydrophobic Moment 0.11

Boman Index0.63

Instability Index19.75

Aliphatic Index 203.64

Aromaticity 0.0909

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 423.29

LogP 0.07

H-bond Donors 14.0

H-bond Acceptors 15.0

Rotatable Bonds 36.0

Heavy Atoms 86.0

Ring Count 2.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0247980 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/