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MYP_080962
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Basic Information
Varv peptide F
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C122H192N34O41S6
Standard
Sequence
GVPICGETCTLGTCYTAGCSCSWPVCTRN
Physicochemical Analysis
2983.42 Da
5.96
-0.30
-0.59
-0.0103
0.34
0.26
0.19
52.46
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1180.46
-16.92
48.0
47.0
87.0
203.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054738 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Varv peptide
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Leukemia (cell line not reported)
PaperCancerPPD2 curated year-page record; primary PMID 10075760 (1999), additional curated PMID 18957441. PMID10075760;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0064639 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer Cytotoxic
PaperPubMed PMID: 10075760 | PubMed PMID: 12477048 | PubMed PMID: 19211551 PMID10075760;12477048;19211551 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0099415 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclic Peptide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Anticancer Enzymatic-degradation Antimicrobial
Human renal adenocarcinoma ACHN
2.63 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 25815330 PMID25815330;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0110856 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer
ACHN
2.63 μM
IC50
PaperPubMed PMID: 10075760 | PubMed PMID: 12477048 | PubMed PMID: 19211551 PMID10075760;12477048;19211551 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0111116 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclic Peptide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Anticancer Enzymatic-degradation Antimicrobial
Human lung carcinoma A549
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 25815330 PMID25815330;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
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