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MYP_080962
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Basic Information
Varv peptide F
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C122H192N34O41S6
Standard
Sequence
GVPICGETCTLGTCYTAGCSCSWPVCTRN
Physicochemical Analysis
2983.42 Da
5.96
-0.30
-0.59
-0.0103
0.34
0.26
0.19
52.46
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1180.46
-16.92
48.0
47.0
87.0
203.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021293 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Three disulfide bonds
Bio-Activity Profile
Anticancer
MDA-MB-231
Mammalian 30 h; Yeast >20 h; E. coli >10 h
PaperSeven novel macrocyclic polypeptides from Viola arvensis; Cyclotides: a novel type of cytotoxic agents; Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold PMID10075760;12477048;19211551;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0025607 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclic Peptide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Anticancer Enzymatic-degradation Antimicrobial
Human glioblastoma U251-MG
44.49 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 25815330 PMID25815330;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0030553 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Viola arvensis
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Leukemia Cancer (Not Available)
PMID10075760;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0034127 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0053485 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclic Peptide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Anticancer Enzymatic-degradation Antimicrobial
Human hepatocarcinoma BEL-7402
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 25815330 PMID25815330;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
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