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MYP_080962
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Basic Information
Varv peptide F
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C122H192N34O41S6
Standard
Sequence
GVPICGETCTLGTCYTAGCSCSWPVCTRN
Physicochemical Analysis
2983.42 Da
5.96
-0.30
-0.59
-0.0103
0.34
0.26
0.19
52.46
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1180.46
-16.92
48.0
47.0
87.0
203.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001691 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Three disulfide bonds
Bio-Activity Profile
Anticancer
RPMI-8226/LR-5
6.31 μM
IC50
Mammalian 30 h; Yeast >20 h; E. coli >10 h
PaperSeven novel macrocyclic polypeptides from Viola arvensis; Cyclotides: a novel type of cytotoxic agents; Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold PMID10075760;12477048;19211551;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0004273 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0008887 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclic Peptide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Anticancer Enzymatic-degradation Antimicrobial
Human lymphoblastic leukemia CCRF-CEM
7.13 μM
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 25815330 PMID25815330;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25815330/
RECORD: Rec_0014423 VERIFIED: YES
Provenance & Taxonomy
Field pansy [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10075760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
RECORD: Rec_0020310 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer Cytotoxic
U251(IC50=44.49μg/mL), MDA-MB-231(IC50>10μg/mL), A549(IC50>10μg/mL), DU145(IC50>10μg/mL), BEL-7402
10 μg/mL
IC50
PaperPubMed PMID: 10075760 | PubMed PMID: 12477048 | PubMed PMID: 19211551 PMID10075760;12477048;19211551 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10075760/
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