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MYP_080915
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Basic Information
Jindongenin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C111H199N29O33S4
Standard
Sequence
DSMGAVKLAKLLIDKMKCEVTKAC
Physicochemical Analysis
2596.20 Da
8.79
1.74
1.50
0.0725
0.28
0.57
0.03
30.61
101.67
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1015.08
-8.07
37.0
39.0
94.0
177.0
0.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0386495 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans ATCC2002
60 μM
MIC
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
RECORD: Rec_0392787 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumonia
30 μM
MIC
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
RECORD: Rec_0414229 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli ATCC 25922
10 μM
MIC
PaperTwo novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis
RECORD: Rec_0421714 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Jindongenin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
PaperZ. Chen et al. / Biochimie 94 (2012) 328-334. Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis Evidence URLhttps://www.uniprot.org/uniprotkb/G3F826/entry
RECORD: Rec_0426375 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC29212
60 μM
MIC
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
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