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MYP_080915
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Basic Information
Jindongenin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C111H199N29O33S4
Standard
Sequence
DSMGAVKLAKLLIDKMKCEVTKAC
Physicochemical Analysis
2596.20 Da
8.79
1.74
1.50
0.0725
0.28
0.57
0.03
30.61
101.67
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1015.08
-8.07
37.0
39.0
94.0
177.0
0.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006253 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Jindongenin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
150.0 μM
HC50
PaperZ. Chen et al. / Biochimie 94 (2012) 328-334. Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis Evidence URLhttps://www.uniprot.org/uniprotkb/G3ETQ2/entry
RECORD: Rec_0013544 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
40 μM
MIC
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
RECORD: Rec_0016454 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
RECORD: Rec_0020298 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterobacter cloacae ATCC13047
40 μM
MIC
PMID21816202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21816202/
RECORD: Rec_0024387 VERIFIED: YES
Provenance & Taxonomy
Amolops jingdongensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus IS 10#
40 μM
MIC
PaperTwo novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis
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