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MYP_080865
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Basic Information
HeV F HRC derived peptide(449-484)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C177H292N46O63S
Standard
Sequence
VYTDKVDISSQISSMNQSLQQSKDYIKEAQKILDTV
Physicochemical Analysis
4104.55 Da
4.78
-1.26
-1.49
-0.0351
-0.58
0.69
-0.11
45.61
91.94
0.0556
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1833.24
-21.52
62.0
63.0
145.0
287.0
2.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015420 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Fusion inhibition
inhibition of fusion in HeLa cells
10 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 Oct;80(19):9837-49. | DOI:10.1128/JVI.00736-06 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0141246 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 72.2%, E 0.0%, T 2.8%, C 25.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0195784 VERIFIED: YES
Provenance & Taxonomy
Human parainfluenza virus 3 [Virus]
Virus-derived peptide
11216;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Human parainfluenza virus type 3 (Fusion); HeLa
10 μM
Luminescence fusion assay
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0231368 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Fusion inhibition
inhibition of fusion in HeLa cells
0.04 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of hendra virus fusion. | Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. | J Virol. 2006 Oct;80(19):9837-49. | DOI:10.1128/JVI.00736-06 | PMID:16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
RECORD: Rec_0251069 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of fusion in HeLa cells
0.04 μM
IC50
PaperPubMed PMID: 16973588 PMID16973588 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16973588/
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