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MYP_080779
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Basic Information
Peptide PP4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Collagen boosting
Standard
5 amino acids
C23H45N7O9
Standard
Sequence
KTTKS
Physicochemical Analysis
563.64 Da
10.00
1.76
1.55
0.3516
-2.00
0.52
-0.66
8.00
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
292.45
-4.65
11.0
11.0
20.0
39.0
0.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0215735 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Pentapeptide
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Lipoic acid conjugation
Bio-Activity Profile
Anti-aging Collagen boosting Anti-melanogenic
Human Dermal Fibroblasts (KMST-6) (In vitro)
Cell viability assay; Cytotoxicity assay; Cell proliferation assay; ELISA; Tyrosinase assay; Melanin assay; Collagen assay; Histology; Apoptosis assay
PaperSynthesis of lipoic acid-peptide conjugates and their effects on collagen synthesis and melanogenesis PMID24090916 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24090916/
RECORD: Rec_0221472 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: L-Ascorbic acid
Bio-Activity Profile
-
PaperDesign and efficient synthesis of novel ascorbyl conjugated peptide with high collagen biosynthesis stimulating effects Evidence URLhttps://doi.org/10.1016/j.bmcl.2008.10.112
RECORD: Rec_0224358 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 13883
60 μg/mL
MIC
PMID34834377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34834377/
RECORD: Rec_0234058 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC 29212
1820 μM
MIC
PMID31481944 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31481944/
RECORD: Rec_0235379 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC29212
60 μg/mL
MIC
PMID34834377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34834377/
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